We can challenge for elucidation of MAM function under the circumstances, because excellent scientists with a proven track record for MAM research gather in School of life Sciences of Tokyo university of Pharmacy and life Sciences. In cooperation with many experts for various fields in the inside and outside of university, we try to clarify the roles of MAM in organelle dynamics and diseases. This project may contribute greatly to understanding of pathology and development of new treatments for MAM-associated diseases. In addition, we aim for cultivation of young scientists who are responsible for next generation.